Wentworth Miller on House

Former Prison Break hunk Wentworth Miller will guest star in an episode of House.

He last appeared on the small screen in a 2009 guest role on Law & Order: SVU.

Meanwhile, creator David Shore told The Hollywood Reporter that the departure of Lisa Edelstein (Cuddy) was one reason why the producers “decided to have the time passage [in the season opener]. The world outside of House has settled into its own environment and it’s completely different in so many ways, including the fact that Lisa’s not there. House has to adapt.”

He says the show has “always been case-based, but it’ll be more than that. We’re going to have fun with House messing with people. It hasn’t changed that much. It’s a slight shift.”