It has been nominated for Best Comedy, and Zwar and Beth Buchanan have also been nominated in the Most Outstanding Actor and Actress categories.
The show will compete against such titles as Modern Family, 30 Rock and Red Dwarf. It is the only Australian nominee in the prestigious festival.
Nominees in the Best Actress and Actor category include Julie Bowen and Ty Burrell and Tina Fey.
Lowdown is a High Wire Films production, which won an AACTA Award for Best Comedy, two AWGIE Awards for Best Comedy, and the Gold Medal for Best Comedy at the New York Film and Television Festival.
ABC is yet to confirm a third season.